Should aspirin be used for primary prevention?

Should Aspirin Be Used for the Primary Prevention of Cardiovascular Disease in the General Population?

were sponsored by pharmaceutical companies, so publication and reporting bias may well exist among these studies. Some published meta-analyses suggest that the benefits of aspirin utilization in primary CVD may outweigh the risk of bleeding [6–8] . Raju et al. [8] reported that aspirin can increase the risk of hemorrhagic stroke (RR 1.36; 95% CI 1.01–1.82), major bleeding (RR 1.66; 95% CI 1.41–...

Should aspirin be used for the primary prevention of cardiovascular disease in people with diabetes?

TO THE EDITOR: The ASPREE (ASPirin in Reducing Events in the Elderly) study may provide useful data on the benefits and risks of aspirin therapy in patients aged 70 years, as described by Woods and colleagues. However, the decision to allow general practitioner co-investigators to “help decide whether the patient is a suitable candidate for the placebocontrolled trial” introduces a source of se...

Should patients stop taking aspirin for primary prevention?

Should levodopa be used anymore?

Levodopa is the most potent dopaminergic oral drug available in clinical practice. After chronic treatment, many patients with Parkinson's disease develop dyskinesia and motor fluctuations which are difficult to manage. It was hoped that introduction of dopaminergic agonists could diminish these side effects while keeping the same efficacy as levodopa. Prospective clinical data do not support t...

Point/Counterpoint: Aspirin should not be promoted for colon cancer prevention: counterpoint.

There is little question that aspirin can decrease the risk of large bowel cancer. A large number of observational studies in humans, both case-control and cohort, consistently show a strong protective effect of aspirin (1). Importantly, three randomized controlled trials show that aspirin decreases the risk of new adenomas in humans (2-4). Because most colorectal cancers arise from adenomas, t...